Randomised controlled trial of combined paracetamol and ibuprofen for fever.
نویسندگان
چکیده
A randomised open label study of the combined use of paracetamol and ibuprofen to rapidly reduce fever is reported. The advantage of using both medications is less than half a degree centigrade in the first hour, and insufficient to warrant routine use.
منابع مشابه
Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial
OBJECTIVE To investigate whether paracetamol (acetaminophen) plus ibuprofen are superior to either drug alone for increasing time without fever and the relief of fever associated discomfort in febrile children managed at home. DESIGN Individually randomised, blinded, three arm trial. SETTING Primary care and households in England. PARTICIPANTS Children aged between 6 months and 6 years wi...
متن کاملParacetamol plus ibuprofen for the treatment of fever in children (PITCH): economic evaluation of a randomised controlled trial
OBJECTIVE To estimate the cost to the NHS and to parents and carers of treating febrile preschool children with paracetamol, ibuprofen, or both, and to compare these costs with the benefits of each treatment regimen. DESIGN Cost consequences analysis and cost effectiveness analysis conducted as part of a three arm, randomised controlled trial. PARTICIPANTS Children between the ages of 6 mon...
متن کاملPISA. The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: Protocol for a phase II double-blind randomised placebo-controlled trial [ISRCTN98608690]
BACKGROUND During the first days after stroke, one to two fifths of the patients develop fever or subfebrile temperatures. Body temperature is a strong prognostic factor after stroke. Pharmacological reduction of temperature in patients with acute ischaemic stroke may improve their functional outcome. Previously, we studied the effect of high dose (6 g daily) and low dose (3 g daily) paracetamo...
متن کاملSystematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone.
OBJECTIVE To evaluate the evidence surrounding the use of combinations of paracetamol and ibuprofen in the treatment of fever. DESIGN Systematic narrative review of randomised controlled trials using the UK Economic and Social Research Council guidance on the conduct of narrative synthesis. SETTING Inpatient, outpatient and home care. PATIENTS Children with fever. MAIN OUTCOME MEASURES ...
متن کاملParacetamol and ibuprofen for the treatment of fever in children: the PITCH randomised controlled trial.
OBJECTIVES To establish the relative clinical effectiveness and cost-effectiveness of paracetamol plus ibuprofen compared with paracetamol and ibuprofen separately for time without fever, and the relief of fever-associated discomfort in young children who can be managed at home. DESIGN The trial design was a single-centre (multisite), individually randomised, blinded, three-arm trial comparin...
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 91 5 شماره
صفحات -
تاریخ انتشار 2006